🎉 MILESTONE: Weekly check-in thread March 10–16, 2026!

I can not believe I am typing this. When I started this journey I had zero hope.

Numbers: BMI went from 42 to 25.

Thank you to this community for keeping me sane through the hard parts. You know who you are. 🙏

mike_mod's experience with Weekly check-in thread resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 48 lbs in 13 months.

One thing I would add that mike_mod did not mention: the relationship with food fundamentally changed.

Thanks for sharing this, mike_mod. A few questions about your Weekly check-in experience:

1. What dose worked best for you?
2. How long before you noticed appetite suppression kicking in?
3. Did your endo have any specific recommendations about Weekly check-in?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Weekly check-in thread .

To answer SallyK_inj: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Weekly check-in thread March — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 221 → 91 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.