Mar 4, 2026 at 1:02 PM#6
Yep. My endo said the same thing about GLP-1 receptor.
36 9LeilaHI, marcus_mpls, DeniseRN_TPA and 33 others
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Mar 4, 2026 at 1:19 PM#7
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 receptor expression.
To answer LarryQC_SD: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
19 16Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 16 others
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Mar 4, 2026 at 1:36 PM#8
Adding my data to this GLP-1 receptor expression discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 250 lbs | 235 lbs | 195 lbs |
| A1C | 6.4% | 5.8% | 5.4% |
| hsCRP | 4.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.
Last edited: Mar 4, 2026 at 7:36 PM
31 8WendyG_ATL, SaraMom3, Dr.MetabolicMD and 28 others
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View ResultsMar 4, 2026 at 1:53 PM#9
+1 to Dr.CardioMD. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with GLP-1 receptor expression.
3 24LibrarianMeg, bri_stats, pete_manc_UK
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Mar 4, 2026 at 2:10 PM#10
Slightly tangential to GLP-1 receptor expression but JakeSmashed95 reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Last edited: Mar 4, 2026 at 6:10 PM
27 17CarlaRPh_TPA, steph_laguna, fiona_glasgow and 24 others
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