Same experience here with WELCOME Introduce. PharmHunterJen described it perfectly.

Clinical perspective on WELCOME Introduce yourself & read the:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

Want to share my personal experience related to WELCOME Introduce yourself & since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 262 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 62 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The WELCOME Introduce aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

PharmHunterJen — that is really helpful context on WELCOME Introduce. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

To answer CryptoCarl's question specifically:

From a clinical standpoint, WELCOME Introduce yourself & is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.