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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOral GLP-1 for elderly patients — anyone have experience?

Oral GLP-1 for elderly patients — anyone have experience?

EndoResFellow Wed, Apr 16, 2025 at 4:27 AM 45 replies 2,071 viewsPage 1 of 9
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EndoResFellow
Member
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Sep 2024
Baltimore, MD
Apr 16, 2025 at 5:52 AM#1

Oral GLP-1 for elderly patients — anyone have experience?

Curious where everyone stands on this. I have seen strong opinions both ways in other threads and want to get a proper read on the community consensus.

For context: oral glp-1 for elderly patients anyone is something I've been going back and forth on. Some members seem to swear by one approach, others recommend the opposite.

Drop your experience below — even if it is just a quick "this worked" or "this did not work" that helps. Detailed responses obviously welcome too.

Let's get some data points going 📊

5 11robert_kc, dan_philly, MeganSA_TX and 2 others
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Dr.AddMedPHL
Senior Member
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Mar 2024
Philadelphia, PA
Apr 16, 2025 at 6:09 AM#2

EndoResFellow's experience with Oral GLP-1 for elderly resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 69 lbs in 14 months.

One thing I would add that EndoResFellow did not mention: insurance coverage was a major hurdle.

Last edited: Apr 16, 2025 at 8:09 AM
32 8sarah_nash92, FitDadDave, RunnerRach and 29 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Apr 16, 2025 at 6:26 AM#3

Thanks for sharing this, EndoResFellow. A few questions about your Oral GLP-1 for experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Oral GLP-1 for?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

28 6Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 25 others
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EndoResFellow
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Sep 2024
Baltimore, MD
Apr 16, 2025 at 6:43 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral GLP-1 for elderly.

To answer carlos_SATX: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

11 0NurseKim_ATL, paul_denver, TinaHashiRN and 8 others
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lucas_SP_BR
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Jun 2024
São Paulo, BR
Apr 16, 2025 at 7:00 AM#5

Adding my data to this Oral GLP-1 for elderly discussion:

MetricBaselineMonth 5Month 6
Weight252 lbs242 lbs197 lbs
A1C6.6%6.0%5.2%
hsCRP6.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

21 23tampaLisa73, KarenAZ_mom, zoe_NC and 18 others
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