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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — leucine threshold discussion Page 3

Muscle protein synthesis rates on GLP-1 — leucine threshold discussion

ChrisMacros Fri, Feb 27, 2026 at 8:37 AM 21 replies 460 viewsPage 3 of 5
ben_calgary
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Feb 27, 2026 at 12:52 PM#11
LipidDoc_ATL said:
Muscle protein synthesis rates on is not that straightforward in my experience

This is exactly right. LipidDoc_ATL articulated what I have been trying to explain to my friends for months. The Muscle protein synthesis aspect is what made the difference for me.

Last edited: Feb 27, 2026 at 6:52 PM
30 18KetoKyle, CanadaChris, ZaraB_AL and 27 others
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SarahChen_PharmD
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San Diego, CA
Feb 27, 2026 at 1:09 PM#12

Reading this thread on Muscle protein synthesis hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Muscle protein — take the leap. It was the best health decision I have ever made. ❤️

20 7NurseKim_ATL, paul_denver, TinaHashiRN and 17 others
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chris_chi24
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Sep 2024
Chicago, IL
Feb 27, 2026 at 1:26 PM#13

Dr.Martinez — that is really helpful context on Muscle protein synthesis. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

13 15MaxMetOK, MounjBrad, nick_newbie and 10 others
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GenomicsKate
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Oct 2024
Cambridge, MA
Feb 27, 2026 at 1:43 PM#14

To answer SarahChen_PharmD's question specifically:

From a clinical standpoint, Muscle protein synthesis rates is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

21 1Dr.PeteFamMed, claudia_zurich, nancy_portland and 18 others
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MeganSA_TX
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San Antonio, TX
Feb 27, 2026 at 2:00 PM#15

Bookmarked 📌 The Muscle protein info in this thread is essential. Coming back to this for sure.

14 11mike.trainer_LA, sarah_nash92, FitDadDave and 11 others
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