LipidDoc_ATL said:

Muscle protein synthesis rates on is not that straightforward in my experience

This is exactly right. LipidDoc_ATL articulated what I have been trying to explain to my friends for months. The Muscle protein synthesis aspect is what made the difference for me.

Reading this thread on Muscle protein synthesis hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Muscle protein — take the leap. It was the best health decision I have ever made. ❤️

Dr.Martinez — that is really helpful context on Muscle protein synthesis. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

To answer SarahChen_PharmD's question specifically:

From a clinical standpoint, Muscle protein synthesis rates is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Bookmarked 📌 The Muscle protein info in this thread is essential. Coming back to this for sure.