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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — leucine threshold discussion Page 4

Muscle protein synthesis rates on GLP-1 — leucine threshold discussion

ChrisMacros Fri, Feb 27, 2026 at 8:37 AM 21 replies 460 viewsPage 4 of 5
ChrisMacros
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Feb 27, 2026 at 2:17 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Muscle protein synthesis.

To answer SarahChen_PharmD: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

34 9RunnerRach, TrialNerd_Beth, HPLC_Greg and 31 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Feb 27, 2026 at 2:34 PM#17

Adding my data to this Muscle protein synthesis discussion:

MetricBaselineMonth 3Month 6
Weight276 lbs216 lbs201 lbs
A1C7.0%5.8%5.2%
hsCRP5.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

Last edited: Feb 27, 2026 at 5:34 PM
23 3hank_denver, carlos_SATX, sophie_paris and 20 others
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fiona_VT
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Dec 2024
Vermont
Feb 27, 2026 at 2:51 PM#18

Exactly this. My pharmacist said the same thing about Muscle protein.

Last edited: Feb 27, 2026 at 3:51 PM
46 19jason_sac26, chris_chi24, tampaLisa73 and 43 others
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Dr.KarenChen
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San Francisco, CA
Feb 27, 2026 at 3:08 PM#19

Slightly tangential to Muscle protein synthesis but ben_calgary reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 27, 2026 at 9:08 PM
32 14mike.trainer_LA, sarah_nash92, FitDadDave and 29 others
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JakeSmashed95
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Aug 2024
Arkansas
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Feb 27, 2026 at 3:25 PM#20

+1 to ChrisMacros. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Muscle protein synthesis.

11 15tammy_FL, Dr.LipidDallas, alex_tucson and 8 others
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