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ForumsCompounding & FormulationEndotoxin testing in compounded injectables — LAL vs rFC methods Page 2

Endotoxin testing in compounded injectables — LAL vs rFC methods

LabKate Wed, Mar 11, 2026 at 12:43 AM 17 replies 423 viewsPage 2 of 4
pam_columbus
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Columbus, OH
Mar 11, 2026 at 3:33 AM#6

I'll vouch for Janoshik's reliability. I've sent split samples — same vial, tested both at Janoshik and at a CLIA-certified US lab. Results were within 2% of each other on potency (HPLC). That's well within inter-laboratory variability.

The turnaround time can be slow during their busy periods (after holidays, etc.) but results have always been thorough. Their reports include full chromatograms, peak integration data, and a clear pass/fail assessment. 📈

Last edited: Mar 11, 2026 at 9:33 AM
1 18kevin_tulsa
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Dr.PeteFamMed
Senior Member
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9,234
Jan 2024
Minneapolis, MN
Mar 11, 2026 at 3:50 AM#7

OK so let me do the math on whether testing is "worth it":

  • Janoshik full panel: ~$130
  • International shipping: ~$55
  • Sample cost (0.5mL of my $150 vial): ~$37.50
  • Total cost of testing: ~$222.50

My monthly compounded sema cost: $150. So testing one batch costs more than one month of medication. Is it worth it for every batch? Probably not. But for your first batch from a new pharmacy? Absolutely. Test once to establish trust, then periodically retest (maybe every 3-6 months) to verify consistency.

Last edited: Mar 11, 2026 at 4:50 AM
50 11tommy_boulder, hyun_seoul, jim_asheville and 47 others
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adam_van
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Nov 2024
Vancouver, CA
Mar 11, 2026 at 4:07 AM#8

That makes sense — test the first batch and then spot-check occasionally. I'm going to submit my sample this week. Will report back with results!

One more thing — should I tell my pharmacy I'm sending their product for third-party testing? Or is that going to cause issues?

Last edited: Mar 11, 2026 at 8:07 AM
3 19LindaRN_retired, tommy_boulder, hyun_seoul
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DataDave
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Apr 2024
Washington
Online
Mar 11, 2026 at 4:24 AM#9

You don't have to tell them, and honestly it's better if you don't — at least not before you get results. If they know you're testing, a bad actor could selectively send you a "good" batch next time. Test first, then share results with them if you want to see their response.

A pharmacy that's confident in their product will welcome third-party verification. One that gets defensive or tries to discredit the testing lab? That tells you everything. 🎯

16 23amsterdam_pete, LondonLisa, mike_nyc and 13 others
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LipidDoc_ATL
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Apr 2024
Atlanta, GA
Mar 11, 2026 at 4:41 AM#10

One last pro tip: when you get your results, share them here (anonymized if you want). Community-sourced testing data is one of the most valuable resources we have. Every data point helps everyone make better decisions. We maintain a community testing database spreadsheet — link is in the sidebar — where members voluntarily contribute their results. Over 200 entries so far across multiple pharmacies.

Knowledge is power. Test your stuff. 💪🔬

31 9KristenIndy, MarkLI_maint, Dr.PeteFamMed and 28 others
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