Feb 16, 2026 at 3:55 PM#16
Congrats Dr.NateNeph!! You should be so proud of yourself. 🎉 👏
48 15CryptoCarl, MariaRD, AussieAnna and 45 others
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Feb 16, 2026 at 4:12 PM#17
Slightly tangential to Pharmacogenomics of GLP-1 but julia.endo reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
28 21TrialTracker_MD, JennaRN, LabKate and 25 others
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Feb 16, 2026 at 4:29 PM#18
Adding my data to this Pharmacogenomics of GLP-1 discussion:
| Metric | Baseline | Month 5 | Month 6 |
|---|---|---|---|
| Weight | 264 lbs | 224 lbs | 209 lbs |
| A1C | 6.8% | 6.0% | 5.2% |
| hsCRP | 8.0 | 4.0 | 0.6 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.
16 3RetaRick_CA, JenPlateau, SallyK_inj and 13 others
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View ResultsFeb 16, 2026 at 4:46 PM#19
Reading this thread on Pharmacogenomics of GLP-1 hits close to home. Night shift nurse — I started at 275 lbs and felt like I would tried everything.
11 months on tirz and I am a different person. Not just the 50 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Pharmacogenomics of — take the leap. It was the best health decision I have ever made. ❤️
Last edited: Feb 16, 2026 at 6:46 PM
31 5lori_vegas, Dr.PulmRoch, maya_sedona and 28 others
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Feb 16, 2026 at 5:03 PM#20
MASHdoc_SA — that is really helpful context on Pharmacogenomics of GLP-1. Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
43 2marco_milano, pam_columbus, nick_SD_fit and 40 others
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