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ForumsPublic SquareGLP-1 and inflammatory markers — CRP, IL-6, TNF-α reduction data Page 3

GLP-1 and inflammatory markers — CRP, IL-6, TNF-α reduction data

Dr.MetabolicMD Wed, Feb 11, 2026 at 4:24 AM 16 replies 510 viewsPage 3 of 4
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Feb 11, 2026 at 8:39 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

33 18PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 30 others
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Dr.ObesityMed
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Feb 11, 2026 at 8:56 AM#12

Slightly tangential to GLP-1 and inflammatory but DataDave reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

38 12PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 35 others
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MikeKY_noInsulin
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Feb 11, 2026 at 9:13 AM#13
maya_sedona said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. maya_sedona articulated what I have been trying to explain to my doctor for months. The GLP-1 and inflammatory aspect is the most important factor.

Last edited: Feb 11, 2026 at 12:13 PM
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tommy_boulder
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Feb 11, 2026 at 9:30 AM#14

Saving this for reference. Top-tier content.

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Dr.NateNeph
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Feb 11, 2026 at 9:47 AM#15

Adding my data to this GLP-1 and inflammatory discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs217 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

6 4RickReta_CO, PharmHunterJen, TomTeleRx and 3 others
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