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ForumsPublic SquareGLP-1 discontinuation: weight regain trajectory and mitigation strategies Page 3

GLP-1 discontinuation: weight regain trajectory and mitigation strategies

Dr.ObesityMed Mon, Jan 26, 2026 at 9:31 PM 16 replies 674 viewsPage 3 of 4
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Jan 27, 2026 at 1:46 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

19 8PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 16 others
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MikeFit_NJ
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Jan 27, 2026 at 2:03 AM#12

Slightly tangential to GLP-1 discontinuation but LipidDoc_ATL reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jan 27, 2026 at 5:03 AM
39 12marcus_mpls, DeniseRN_TPA, SandraNC_45 and 36 others
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Dr.SleepRoch
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Jan 27, 2026 at 2:20 AM#13
SandraNC_45 said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. SandraNC_45 articulated what I have been trying to explain to my doctor for months. The GLP-1 discontinuation aspect is the most important factor.

Last edited: Jan 27, 2026 at 6:20 AM
6 18Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 3 others
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DebRD_ATL
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Jan 27, 2026 at 2:37 AM#14

Saving this for reference. Top-tier content.

42 23PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 39 others
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Dr.PulmRoch
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Jan 27, 2026 at 2:54 AM#15

Adding my data to this GLP-1 discontinuation discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs227 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

37 2KristenIndy, MarkLI_maint, Dr.PeteFamMed and 34 others
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