+1 to LibrarianMeg. Especially the point about "NateNeph perspective but I think this ov..." — I have seen the same in my own experience with Orforglipron and hepatic.

Want to share my personal experience related to Orforglipron and hepatic since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 285 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 45 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Orforglipron and aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

TrialTracker_MD — that is really helpful context on Orforglipron and hepatic. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

To answer sarah_TO's question specifically:

From a clinical standpoint, Orforglipron and hepatic is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

Saving this for reference. Quality thread.