Nov 6, 2024 at 3:29 AM#26
Can confirm — my data shows the same pattern.
8 10PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 5 others
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Nov 6, 2024 at 3:46 AM#27
NurseKim_ATL said:I started my GLP-1 journey in March 2025 at 280 lbs with metabolic syndrome
Gonna push back on this one. Orforglipron and hepatic first-pass is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.
Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.
25 17roxy_nash, tony_orlando, Dr.NephBHM_UK and 22 others
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Nov 6, 2024 at 4:03 AM#28
Want to share my personal experience related to Orforglipron and hepatic since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 286 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 18 months later: I am down 46 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Orforglipron and aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
38 5jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 35 others
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Sigma-Aldrich — Research-Grade Standards
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Shop Reference StandardsNov 6, 2024 at 4:37 AM#30
MikeNYC_runner — that is really helpful context on Orforglipron and hepatic. Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
17 11TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 14 others
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