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ForumsPublic SquareAmylin co-agonism: CagriSema REDEFINE results and implications Page 3

Amylin co-agonism: CagriSema REDEFINE results and implications

Dr.KarenChen Mon, Jan 12, 2026 at 10:16 AM 16 replies 868 viewsPage 3 of 4
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Jan 12, 2026 at 2:31 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Jan 12, 2026 at 6:31 PM
28 13PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 25 others
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Dr.BariatricHTX
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Jan 12, 2026 at 2:48 PM#12

Slightly tangential to Amylin co-agonism but labquiet_amy reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

50 9pete_RVA, CarlaRPh_TPA, steph_laguna and 47 others
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DadBodDave
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Jan 12, 2026 at 3:05 PM#13
anna.melb_AU said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. anna.melb_AU articulated what I have been trying to explain to my doctor for months. The Amylin co-agonism aspect is the most important factor.

Last edited: Jan 12, 2026 at 6:05 PM
23 11pat_auckland, Dr.GastroMayo, JakeBK_lifts and 20 others
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HPLC_Greg
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Jan 12, 2026 at 3:22 PM#14

Saving this for reference. Top-tier content.

Last edited: Jan 12, 2026 at 9:22 PM
21 13Dr.MetabolicMD, RetaRick_CA, JenPlateau and 18 others
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anders_CPH
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Jan 12, 2026 at 3:39 PM#15

Adding my data to this Amylin co-agonism discussion:

MetricBaselineMonth 5Month 8
Weight254 lbs224 lbs209 lbs
A1C6.8%6.0%5.4%
hsCRP8.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Jan 12, 2026 at 7:39 PM
4 12ChrisMacros, KetoKyle, CanadaChris and 1 other
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