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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with oral semaglutide bioavailability optimization? Page 5

Has anyone dealt with oral semaglutide bioavailability optimization?

quinn_sf Fri, Oct 25, 2024 at 3:30 PM 21 replies 1,668 viewsPage 5 of 5
KarenAZ_mom
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Oct 25, 2024 at 10:35 PM#21

chris_chi24 — that is really helpful context on Has anyone dealt with. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Oct 26, 2024 at 3:35 AM
30 23anna.melb_AU, mark_tokyo, hans_munich and 27 others
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pat_auckland
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Auckland, NZ
Oct 25, 2024 at 10:52 PM#22

To answer Dr.NephBHM_UK's question specifically:

From a clinical standpoint, Has anyone dealt with oral is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

12 14wanda_boise, NurseAsh_DET, BenResearch_OR and 9 others
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jason_sac26
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Sacramento, CA
Oct 25, 2024 at 11:09 PM#23

Thank you KarenAZ_mom! This is incredibly helpful. Taking this to my next appointment. 🙏

50 20stefan_berlin, Dr.EM_Chicago, pete_RVA and 47 others
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Dr.RaviCardio
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Oct 25, 2024 at 11:26 PM#24

Relevant to Has anyone dealt with oral — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 247 → 117 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Oct 26, 2024 at 12:26 AM
27 3hans_munich, jason_sac26, chris_chi24 and 24 others
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rick_sfbay
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Jan 2025
San Francisco, CA
Oct 25, 2024 at 11:43 PM#25

Slightly tangential to Has anyone dealt with but KarenAZ_mom reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

30 10Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 27 others
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