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ForumsOral GLP-1 AgonistsOral GLP-1 adherence — 12 month update

Oral GLP-1 adherence — 12 month update

patPC_UT Sat, Sep 21, 2024 at 11:10 AM 46 replies 2,424 viewsPage 1 of 10
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patPC_UT
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Nov 2024
Park City, UT
Sep 21, 2024 at 12:35 PM#1

Hot take incoming: oral glp-1 adherence 12 month update.

I know this is controversial here but I think the conventional wisdom on this topic might be overly simplistic. Before you grab your pitchforks, hear me out.

My argument is based on conversations with my provider who has a different perspective.

Change my mind. Seriously — I want to be wrong about this if I am.

45 15sarah_nash92, FitDadDave, RunnerRach and 42 others
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PharmacoVig_BOS
Senior Member
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8,901
Feb 2024
Boston, MA
Sep 21, 2024 at 12:52 PM#2

patPC_UT's experience with Oral GLP-1 adherence 12 resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 33 lbs in 8 months.

One thing I would add that patPC_UT did not mention: insurance coverage was a major hurdle.

Last edited: Sep 21, 2024 at 3:52 PM
8 20Dr.GutHealth, amsterdam_pete, LondonLisa and 5 others
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chris_chi24
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Sep 2024
Chicago, IL
Sep 21, 2024 at 1:09 PM#3

Thanks for sharing this, patPC_UT. A few questions about your Oral GLP-1 adherence experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Oral GLP-1 adhe?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Sep 21, 2024 at 4:09 PM
36 14MaxMetOK, MounjBrad, nick_newbie and 33 others
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patPC_UT
Member
212
890
Nov 2024
Park City, UT
Sep 21, 2024 at 1:26 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral GLP-1 adherence 12.

To answer chris_chi24: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

14 15JessicaM_2024, TomFromTexas, mike.trainer_LA and 11 others
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TirzTom
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Feb 2024
Florida
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Sep 21, 2024 at 1:43 PM#5

Adding my data to this Oral GLP-1 adherence 12 discussion:

MetricBaselineMonth 5Month 6
Weight256 lbs246 lbs221 lbs
A1C7.0%6.0%5.2%
hsCRP5.04.00.6

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

23 14DeniseRN_TPA, SandraNC_45, Dr.EndoIndy and 20 others
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