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ForumsOral GLP-1 AgonistsOral sema empty stomach requirement — anyone have experience? Page 5

Oral sema empty stomach requirement — anyone have experience?

Dr.LeslieOBGYN Mon, Aug 5, 2024 at 3:35 AM 57 replies 3,155 viewsPage 5 of 12
PharmD_Rodriguez
Senior Member
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Jan 2024
Miami, FL
Aug 5, 2024 at 10:40 AM#21

Want to share my personal experience related to Oral sema empty stomach since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 259 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 84 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Oral sema empty aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

23 12paul_denver, TinaHashiRN, robert_kc and 20 others
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lucas_SP_BR
Member
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Jun 2024
São Paulo, BR
Aug 5, 2024 at 10:57 AM#22

Relevant to Oral sema empty stomach — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Aug 5, 2024 at 12:57 PM
36 18Dr.ObesityLA, NurseKim_ATL, paul_denver and 33 others
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tommy_boulder
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Nov 2024
Boulder, CO
Aug 5, 2024 at 11:14 AM#23

Want to share my personal experience related to Oral sema empty stomach since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 276 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 36 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Oral sema empty aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

27 4robert_kc, dan_philly, MeganSA_TX and 24 others
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anna.melb_AU
Member
678
2,890
Apr 2024
Melbourne, AU
Aug 5, 2024 at 11:31 AM#24

lucas_SP_BR — that is really helpful context on Oral sema empty stomach. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Last edited: Aug 5, 2024 at 3:31 PM
21 18tammy_FL, Dr.LipidDallas, alex_tucson and 18 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Aug 5, 2024 at 11:48 AM#25

Want to share my personal experience related to Oral sema empty stomach since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 248 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 43 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Oral sema empty aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

13 19tommy_boulder, hyun_seoul, jim_asheville and 10 others
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