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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCompounding & FormulationIs it normal for the powder to not fully dissolve Page 2

Is it normal for the powder to not fully dissolve

jason_sac26 Mon, Jan 26, 2026 at 5:29 PM 10 replies 610 viewsPage 2 of 2
BariatricNurseD
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Jan 26, 2026 at 8:19 PM#6
Dr.NutriCornell said:
Short answer: talk to your prescriber first

Gonna push back on this one. Is it normal for the powder to not is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

28 0tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 25 others
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HPLC_Greg
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Jan 26, 2026 at 8:36 PM#7

Adding my data to this Is it normal for the discussion:

MetricBaselineMonth 3Month 8
Weight270 lbs225 lbs195 lbs
A1C6.4%5.8%5.4%
hsCRP4.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

11 20JenPlateau, SallyK_inj, CryptoCarl and 8 others
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NauseaFreeNow
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Jan 26, 2026 at 8:53 PM#8

james_edin — wow. I've been looking for this exact info for weeks.

Last edited: Jan 27, 2026 at 12:53 AM
6 5Dr.PulmRoch, maya_sedona, stefan_berlin and 3 others
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tony_orlando
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Orlando, FL
Jan 26, 2026 at 9:10 PM#9

Slightly tangential to Is it normal for the but VanRx_Mike reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

39 13CanadaChris, ZaraB_AL, JakeSmashed95 and 36 others
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mike_mod
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Jan 26, 2026 at 9:27 PM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

9 13PurityPaulOR, MaxMetOK, MounjBrad and 6 others
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