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ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 5

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Wed, Jul 24, 2024 at 12:13 AM 31 replies 2,377 viewsPage 5 of 7
FranDenver
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Jul 24, 2024 at 7:18 AM#21

DerekSJ_a1c — that is really helpful context on Has anyone dealt with. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jul 24, 2024 at 1:18 PM
34 11Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 31 others
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Dr.CardioMD
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Cleveland, OH
Jul 24, 2024 at 7:35 AM#22

To answer CryptoCarl's question specifically:

From a clinical standpoint, Has anyone dealt with rybelsus is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

35 3Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 32 others
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paige_pharma
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Sep 2024
Omaha, NE
Jul 24, 2024 at 7:52 AM#23

Thank you FranDenver! This is incredibly helpful. Bookmarking for later. 🙏

4 10adam_van, Dr.SurgeonPGH, rachel_ABQ and 1 other
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PharmacoVig_BOS
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Boston, MA
Jul 24, 2024 at 8:09 AM#24

Relevant to Has anyone dealt with rybelsus — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

29 4kate.chem, DataDave, Dr.GutHealth and 26 others
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GraceAZ_72
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Jan 2025
Tucson, AZ
Jul 24, 2024 at 8:26 AM#25

Slightly tangential to Has anyone dealt with but FranDenver reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jul 24, 2024 at 12:26 PM
29 9RetaRick_CA, JenPlateau, SallyK_inj and 26 others
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