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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 6

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Wed, Jul 24, 2024 at 12:13 AM 31 replies 2,377 viewsPage 6 of 7
sarah_TO
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278
1,234
Sep 2024
Toronto, CA
Jul 24, 2024 at 8:43 AM#26

+1 to paige_pharma. Especially the point about "This is incredibly helpful..." — I have seen the same in my own experience with Has anyone dealt with.

Last edited: Jul 24, 2024 at 12:43 PM
29 0andrew_nyc, Dr.EndoEP, GraceAZ_72 and 26 others
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JenPlateau
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Nov 2024
Missouri
Jul 24, 2024 at 9:00 AM#27

Bookmarked 📌 The Has anyone dealt info in this thread is essential. Coming back to this for sure.

36 19TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 33 others
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Dr.AddMedPHL
Senior Member
1,234
6,234
Mar 2024
Philadelphia, PA
Jul 24, 2024 at 9:17 AM#28

Clinical perspective on Has anyone dealt with rybelsus:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

Last edited: Jul 24, 2024 at 11:17 AM
15 0mike.trainer_LA, sarah_nash92, FitDadDave and 12 others
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KarenAZ_mom
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567
2,567
Aug 2024
Scottsdale, AZ
Jul 24, 2024 at 9:34 AM#29

Want to share my personal experience related to Has anyone dealt with rybelsus since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 263 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 63 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Has anyone dealt aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

12 20LibrarianMeg, bri_stats, pete_manc_UK and 9 others
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emma_london
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1,456
Oct 2024
London, UK
Jul 24, 2024 at 9:51 AM#30

Just wanted to say — for anyone reading this Has anyone dealt thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

34 12julia.endo, JessicaM_2024, TomFromTexas and 31 others
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