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ForumsOral GLP-1 AgonistsOral GLP-1 for elderly patients — need advice

Oral GLP-1 for elderly patients — need advice

COA_Karl Sat, Jun 29, 2024 at 8:32 AM 11 replies 1,864 viewsPage 1 of 3
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COA_Karl
Senior Member
2,123
8,901
Jan 2024
Pennsylvania
Jun 29, 2024 at 9:57 AM#1

Can I just vent for a second about oral glp-1 for elderly patients need?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily — just solidarity. Anyone else going through this right now?

47 17matt_MKE, Dr.ReproEndo, lucas_SP_BR and 44 others
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NeuroNate
Senior Member
2,890
16,789
Dec 2023
Chicago, IL
Jun 29, 2024 at 10:14 AM#2

COA_Karl's experience with Oral GLP-1 for elderly resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 64 lbs in 9 months.

One thing I would add that COA_Karl did not mention: the relationship with food fundamentally changed.

17 23wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 14 others
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mona_PHX
Member
189
890
Dec 2024
Phoenix, AZ
Jun 29, 2024 at 10:31 AM#3

Thanks for sharing this, COA_Karl. A few questions about your Oral GLP-1 for experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Oral GLP-1 for?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

22 14SallyK_inj, CryptoCarl, MariaRD and 19 others
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COA_Karl
Senior Member
2,123
8,901
Jan 2024
Pennsylvania
Jun 29, 2024 at 10:48 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral GLP-1 for elderly.

To answer mona_PHX: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

41 10tommy_boulder, hyun_seoul, jim_asheville and 38 others
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Dr.PulmRoch
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Jun 2024
Rochester, MN
Jun 29, 2024 at 11:05 AM#5

Relevant to Oral GLP-1 for elderly — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 217 → 117 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jun 29, 2024 at 12:05 PM
46 23KristenIndy, MarkLI_maint, Dr.PeteFamMed and 43 others
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