Reading this thread on Orforglipron Phase 2 hits close to home. Dad of 2 checking in — I started at 289 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 64 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Orforglipron Phase 2 — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Relevant to Orforglipron Phase 2 weight — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you RickReta_CO! This is incredibly helpful. Taking this to my next appointment. 🙏

+1 to MikeKY_noInsulin. Especially the point about "Orforglipron Phase 2 is exactly what I'v..." — I have seen the same in my own experience with Orforglipron Phase 2.