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ForumsTirzepatide (Mounjaro / Zepbound)5mg → 10mg → 15mg titration — clinical guidance and real-world data Page 2

5mg → 10mg → 15mg titration — clinical guidance and real-world data

Dr.Martinez Thu, Mar 12, 2026 at 7:41 PM 8 replies 114 viewsPage 2 of 2
roxy_nash
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Dec 2024
Nashville, TN
Mar 12, 2026 at 10:31 PM#6

This is why I tell everyone: the tortoise wins this race. I did 0.25mg for 5 weeks, 0.5mg for 6 weeks, and I'm now 4 weeks into 1.0mg. Zero nausea at any point. My total weight loss is slower than some people here but I've never had a miserable day on this medication. The titration schedule is your friend.

27 7josh_phd_bmore, roxy_nash, tony_orlando and 24 others
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KevinCompounds
VIP Member
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Dec 2023
Nevada
Mar 12, 2026 at 10:48 PM#7
Previously posted:
I will absolutely be going back to 0.5mg next week and I will NOT skip ahead again.

Glad you're feeling better. One more thing to keep in mind — when you do eventually go back to 1.0mg (after 4+ weeks at 0.5mg), the transition should be much smoother because:

  1. Your GI receptors will have had proper time to desensitize at the 0.5mg level
  2. You'll have a higher steady-state baseline from consistent 0.5mg dosing
  3. The relative increase from 0.5→1.0 is a 2x jump, which is the largest percentage jump in the standard titration. After that, 1.0→1.7 is 1.7x and 1.7→2.4 is 1.4x

Some providers even add an intermediate 0.75mg step between 0.5 and 1.0 for patients who are particularly sensitive. Worth discussing if you're worried about a repeat experience.

31 22Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 28 others
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EndoResFellow
Member
456
2,345
Sep 2024
Baltimore, MD
Mar 12, 2026 at 11:05 PM#8

The 0.75mg intermediate step is a great idea. I'll ask my provider. Thanks for the advice, you're a lifesaver on this forum. 🙌

18 5paul_denver, TinaHashiRN, robert_kc and 15 others
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