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ForumsTirzepatide (Mounjaro / Zepbound)Switching from semaglutide to tirzepatide — transition protocol Page 3

Switching from semaglutide to tirzepatide — transition protocol

SarahChen_PharmD Sat, Mar 7, 2026 at 2:18 AM 12 replies 490 viewsPage 3 of 3
andrew_nyc
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Apr 2024
New York, NY
Mar 7, 2026 at 6:33 AM#11

+1. This mirrors my journey exactly. The Switching from discussion here is so valuable.

43 6Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 40 others
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tony_orlando
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1,123
Nov 2024
Orlando, FL
Mar 7, 2026 at 6:50 AM#12

Reading this thread on Switching from hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Switching from — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Mar 7, 2026 at 7:50 AM
43 21JakeSmashed95, NauseaFreeNow, SteveThurs and 40 others
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Admin
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Mar 7, 2026 at 7:07 AM#13

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Last edited: Mar 7, 2026 at 11:07 AM
10 19RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 7 others
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Dr.PulmRoch
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Jun 2024
Rochester, MN
Mar 7, 2026 at 7:24 AM#14

Relevant to Switching from semaglutide to — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

26 9DebRD_ATL, KristenIndy, MarkLI_maint and 23 others
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jason_sac26
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Jan 2026
Sacramento, CA
Mar 7, 2026 at 7:41 AM#15

Congrats andrew_nyc!! You should be so proud of yourself. 🎉

26 2Dr.PulmRoch, maya_sedona, stefan_berlin and 23 others
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