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ForumsCardiovascular OutcomesApoB reduction on tirzepatide — SURPASS lipid substudies Page 3

ApoB reduction on tirzepatide — SURPASS lipid substudies

LipidDoc_ATL Wed, Mar 11, 2026 at 1:31 AM 13 replies 243 viewsPage 3 of 3
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Mar 11, 2026 at 5:46 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Mar 11, 2026 at 9:46 AM
4 21PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 1 other
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Dr.MetabolicMD
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Mar 11, 2026 at 6:03 AM#12

Slightly tangential to ApoB reduction on but COA_Karl reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

13 17PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 10 others
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roxy_nash
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Mar 11, 2026 at 6:20 AM#13
tane_welly said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. tane_welly articulated what I have been trying to explain to my doctor for months. The ApoB reduction on aspect is the most important factor.

18 24tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 15 others
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RetaRick_CA
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Mar 11, 2026 at 6:37 AM#14

Saving this for reference. Top-tier content.

39 11nick_newbie, DadBodDave, AmyNC_wife and 36 others
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anders_CPH
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Mar 11, 2026 at 6:54 AM#15

Adding my data to this ApoB reduction on discussion:

MetricBaselineMonth 5Month 8
Weight278 lbs248 lbs203 lbs
A1C7.2%6.0%5.4%
hsCRP7.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

Last edited: Mar 11, 2026 at 10:54 AM
13 18ChrisMacros, KetoKyle, CanadaChris and 10 others
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