Dr.SportsMedIN — wow. I've been looking for this exact info for weeks.

Slightly tangential to Orforglipron Phase 3 but TomFromTexas reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Thanks for sharing this, TomFromTexas. A few questions about your Orforglipron Phase 3 experience:

1. What dose are you currently on?
2. How long before you noticed significant changes?
3. Did your doctor have any specific recommendations about Orforglipron?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Orforglipron Phase 3.

To answer DerekSJ_a1c: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Orforglipron Phase 3 ATTAIN-1 — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 231 → 101 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.