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ForumsOral GLP-1 AgonistsOral semaglutide 50mg (Rybelsus HD) — 12 month update Page 3

Oral semaglutide 50mg (Rybelsus HD) — 12 month update

LibrarianMeg Mon, Mar 4, 2024 at 6:09 AM 44 replies 2,300 viewsPage 3 of 9
sarah_nash92
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Nashville, TN
Mar 4, 2024 at 10:24 AM#11

+1 to mike_nyc. Especially the point about "SportsMedIN perspective but I think this..." — I have seen the same in my own experience with Oral semaglutide 50mg.

Last edited: Mar 4, 2024 at 4:24 PM
50 24NauseaFreeNow, SteveThurs, B12Beth and 47 others
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VanRx_Mike
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May 2024
Vancouver, CA
Mar 4, 2024 at 10:41 AM#12

Want to share my personal experience related to Oral semaglutide 50mg since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 249 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 79 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Oral semaglutide aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

11 16MikeNYC_runner and 8 others
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sophie_paris
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Nov 2024
Paris, FR
Mar 4, 2024 at 10:58 AM#13

Dr.PathRoch — that is really helpful context on Oral semaglutide 50mg. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

16 22MariaRD, AussieAnna, BethLabQueen and 13 others
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anders_CPH
Senior Member
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Feb 2024
Copenhagen, DK
Mar 4, 2024 at 11:15 AM#14

To answer VanRx_Mike's question specifically:

From a clinical standpoint, Oral semaglutide 50mg is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

Last edited: Mar 4, 2024 at 3:15 PM
47 1BethLabQueen, ChrisMacros, KetoKyle and 44 others
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newstart_MO
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Feb 2026
Springfield, MO
Mar 4, 2024 at 11:32 AM#15

Saving this for reference. Top-tier content.

Last edited: Mar 4, 2024 at 5:32 PM
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