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ForumsPublic SquareSELECT trial 4-year follow-up data released — November 2025 Page 2

SELECT trial 4-year follow-up data released — November 2025

mona_PHX Thu, Oct 2, 2025 at 5:19 AM 10 replies 1,070 viewsPage 2 of 2
Dr.AddMedPHL
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Mar 2024
Philadelphia, PA
Oct 2, 2025 at 8:09 AM#6

Saving this for reference. Quality thread.

Last edited: Oct 2, 2025 at 10:09 AM
42 7FitDadDave, RunnerRach, TrialNerd_Beth and 39 others
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anders_CPH
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Copenhagen, DK
Oct 2, 2025 at 8:26 AM#7

Slightly tangential to SELECT trial 4-year data but RickReta_CO reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Oct 2, 2025 at 12:26 PM
47 17MariaRD, AussieAnna, BethLabQueen and 44 others
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hank_denver
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Denver, CO
Oct 2, 2025 at 8:43 AM#8

+1 to RickReta_CO. Especially the point about "A few questions about your SELECT trial ..." — I have seen the same in my own experience with SELECT trial 4-year data.

18 7denise_HTX, raj_cambridge, ingrid_STO and 15 others
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pete_nash
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Nashville, TN
Oct 2, 2025 at 9:00 AM#9

CarlaRPh_TPA — that is really helpful context on SELECT trial 4-year data. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

49 2SarahChen_PharmD, sarah.morrison, NeuroNate and 46 others
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james_edin
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Sep 2024
Edinburgh, UK
Oct 2, 2025 at 9:17 AM#10

To answer hank_denver's question specifically:

From a clinical standpoint, SELECT trial 4-year data is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

20 2bbq_ray_KC, oliver_london, tane_welly and 17 others
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