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ForumsCardiovascular OutcomesSOUL trial preliminary data — semaglutide in T2DM cardiovascular outcomes Page 3

SOUL trial preliminary data — semaglutide in T2DM cardiovascular outcomes

Dr.CardioMD Sat, Mar 7, 2026 at 1:06 AM 20 replies 546 viewsPage 3 of 4
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Mar 7, 2026 at 5:21 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

25 17PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 22 others
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Dr.PainCLE
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Mar 7, 2026 at 5:38 AM#12

Slightly tangential to SOUL trial preliminary but DataDave reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 7, 2026 at 8:38 AM
3 20tane_welly, Dr.PathRoch, mona_PHX
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robert_kc
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Mar 7, 2026 at 5:55 AM#13
JakeSmashed95 said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. JakeSmashed95 articulated what I have been trying to explain to my doctor for months. The SOUL trial preliminary aspect is the most important factor.

Last edited: Mar 7, 2026 at 7:55 AM
13 5DoseLogDan, SleepFixSam, PurityPaulOR and 10 others
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mike_mealprep
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Mar 7, 2026 at 6:12 AM#14

Saving this for reference. Top-tier content.

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Dr.PathRoch
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Mar 7, 2026 at 6:29 AM#15

Adding my data to this SOUL trial preliminary discussion:

MetricBaselineMonth 4Month 8
Weight250 lbs245 lbs205 lbs
A1C6.4%6.2%5.4%
hsCRP4.03.00.8

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

45 10Dr.MetabolicMD, RetaRick_CA, JenPlateau and 42 others
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