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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — my results so far Page 4

Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

raj_cambridge Fri, Sep 19, 2025 at 6:20 AM 33 replies 1,411 viewsPage 4 of 7
pam_columbus
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Sep 19, 2025 at 12:00 PM#16

Congrats PharmHunterJen!! Keep going — you're doing incredible. 🎉

Last edited: Sep 19, 2025 at 6:00 PM
43 9kevin_tulsa, Dr.PainCLE, mike_mealprep and 40 others
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Dr.Martinez
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Sep 19, 2025 at 12:17 PM#17

raj_cambridge's experience with Is there a ceiling effect resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 61 lbs in 6 months.

One thing I would add that raj_cambridge did not mention: insurance coverage was a major hurdle.

39 15traveltech_sara, AttorneyGrant, DebRD_ATL and 36 others
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KetoKyle
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Sep 19, 2025 at 12:34 PM#18

Bookmarked 📌 The Is there a ceiling info in this thread is essential. Coming back to this for sure.

32 15pat_auckland, Dr.GastroMayo, JakeBK_lifts and 29 others
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TinaHashiRN
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Sep 19, 2025 at 12:51 PM#19

Clinical perspective on Is there a ceiling effect for:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

23 15Admin, Dr.Martinez, mike_mod and 20 others
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MeganSA_TX
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Sep 19, 2025 at 1:08 PM#20

Subscribing to this thread. Is there a ceiling effect is exactly what I've been researching. 🙏

31 12mike.trainer_LA, sarah_nash92, FitDadDave and 28 others
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