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ForumsOral GLP-1 AgonistsOral sema absorption enhancer SNAC — anyone have experience? Page 8

Oral sema absorption enhancer SNAC — anyone have experience?

dave_SLC Mon, Jan 8, 2024 at 11:27 PM 55 replies 2,928 viewsPage 8 of 11
NurseKim_ATL
Senior Member
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Feb 2024
Atlanta, GA
Jan 9, 2024 at 10:47 AM#36

Slightly tangential to Oral sema absorption but CryptoCarl reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

9 15denise_HTX, raj_cambridge, ingrid_STO and 6 others
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TrialTracker_MD
Senior Member
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Jan 2024
Maryland
Jan 9, 2024 at 11:04 AM#37

Relevant to Oral sema absorption enhancer — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 191 → 91 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

34 18stefan_berlin, Dr.EM_Chicago, pete_RVA and 31 others
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pam_stl
Member
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1,123
Oct 2024
St. Louis, MO
Jan 9, 2024 at 11:21 AM#38

Want to share my personal experience related to Oral sema absorption enhancer since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 262 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 67 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Oral sema absorption aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

21 4PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 18 others
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jason_paloalto
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Nov 2024
Palo Alto, CA
Jan 9, 2024 at 11:38 AM#39

MASHdoc_SA — that is really helpful context on Oral sema absorption. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Last edited: Jan 9, 2024 at 4:38 PM
10 22andrew_nyc, Dr.EndoEP, GraceAZ_72 and 7 others
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MikeNYC_runner
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Jul 2024
New York, NY
Jan 9, 2024 at 11:55 AM#40

Want to share my personal experience related to Oral sema absorption enhancer since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 279 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 74 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Oral sema absorption aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Last edited: Jan 9, 2024 at 1:55 PM
47 16MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 44 others
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