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ForumsOral GLP-1 AgonistsOral semaglutide bioavailability optimization — 12 month update Page 6

Oral semaglutide bioavailability optimization — 12 month update

jim_asheville Sun, Nov 12, 2023 at 4:58 PM 58 replies 3,516 viewsPage 6 of 12
jason_sac26
New Member
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Jan 2026
Sacramento, CA
Nov 13, 2023 at 1:28 AM#26

Can confirm — same results here.

32 21pete_RVA, CarlaRPh_TPA, steph_laguna and 29 others
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Dr.ReproEndo
Senior Member
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8,901
Jan 2024
Scottsdale, AZ
Nov 13, 2023 at 1:45 AM#27
mona_PHX said:
I started my GLP-1 journey in October 2024 at 250 lbs with prediabetes and hypertension

Gonna push back on this one. Oral semaglutide bioavailability is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: Nov 13, 2023 at 2:45 AM
21 24andrew_nyc, Dr.EndoEP, GraceAZ_72 and 18 others
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nancy_portland
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Aug 2024
Portland, ME
Nov 13, 2023 at 2:02 AM#28

Want to share my personal experience related to Oral semaglutide since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 256 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 51 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Oral semaglutide aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Last edited: Nov 13, 2023 at 3:02 AM
45 21MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 42 others
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Dr.EndoEP
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Oct 2024
El Paso, TX
Nov 13, 2023 at 2:19 AM#29

Saving this for reference. Quality thread.

13 0Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 10 others
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Dr.EM_Chicago
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May 2024
Chicago, IL
Nov 13, 2023 at 2:36 AM#30

jason_sac26 — that is really helpful context on Oral semaglutide. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Nov 13, 2023 at 6:36 AM
21 9lisa_labSD, adam_van, Dr.SurgeonPGH and 18 others
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