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ForumsCardiovascular OutcomesNNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison Page 6

NNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison

BiostatsBrad Sat, Feb 21, 2026 at 12:55 AM 26 replies 690 viewsPage 6 of 6
james_edin
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289
1,234
Sep 2024
Edinburgh, UK
Feb 21, 2026 at 9:25 AM#26

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 246 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 81 lbs, my labs have normalized, and I am off 2 of my 3 medications. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Feb 21, 2026 at 11:25 AM
1 18mona_PHX
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paul_denver
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723
3,234
May 2024
Denver, CO
Feb 21, 2026 at 9:42 AM#27

JakeSmashed95 — that is really helpful context on NNT for MACE prevention . Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

45 19jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 42 others
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denise_HTX
Member
145
678
Jan 2025
Houston, TX
Feb 21, 2026 at 9:59 AM#28

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 263 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 88 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

35 17JessicaH_TX, KevinCompounds, TirzTom and 32 others
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amy_econ_NJ
Member
567
2,567
May 2024
Princeton, NJ
Feb 21, 2026 at 10:16 AM#29

paul_denver — that is really helpful context on NNT for MACE prevention . Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

2 19gary_naperville, sean_dublin
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NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
Feb 21, 2026 at 10:33 AM#30

Want to share my personal experience related to NNT for MACE prevention since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 280 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 40 lbs, my labs have normalized, and I am off 2 of my 3 medications. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

5 15cory_ATX, lori_vegas, Dr.PulmRoch and 2 others
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