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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide and kidney function — eGFR trends in SURPASS data Page 3

Tirzepatide and kidney function — eGFR trends in SURPASS data

Dr.NateNeph Mon, Feb 2, 2026 at 7:12 AM 12 replies 680 viewsPage 3 of 3
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Feb 2, 2026 at 11:27 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

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mike.trainer_LA
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Feb 2, 2026 at 11:44 AM#12

Slightly tangential to Tirzepatide and kidney but JessicaH_TX reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 2, 2026 at 3:44 PM
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PurityPaulOR
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Feb 2, 2026 at 12:01 PM#13
traveltech_sara said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. traveltech_sara articulated what I have been trying to explain to my doctor for months. The Tirzepatide and kidney aspect is the most important factor.

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RunnerRach
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Feb 2, 2026 at 12:18 PM#14

Saving this for reference. Top-tier content.

Last edited: Feb 2, 2026 at 3:18 PM
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lisa_labSD
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Feb 2, 2026 at 12:35 PM#15

Adding my data to this Tirzepatide and kidney discussion:

MetricBaselineMonth 3Month 8
Weight266 lbs216 lbs201 lbs
A1C7.0%5.8%5.4%
hsCRP5.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

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