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ForumsPublic SquareCost-effectiveness analysis: GLP-1 agonists vs bariatric surgery (ICER 2026) — looking for input

Cost-effectiveness analysis: GLP-1 agonists vs bariatric surgery (ICER 2026) — looking for input

SkepticalSean Wed, Jul 2, 2025 at 2:23 AM 14 replies 1,388 viewsPage 1 of 3
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SkepticalSean
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Maine
Jul 2, 2025 at 3:48 AM#1

Anyone else dealing with cost-effectiveness analysis glp-1 agonists vs bariatric from a cost perspective?

I have been paying $280/month and I am trying to get insurance to cover it.

Share what you are paying and what you are getting — transparency helps everyone.

33 17DerekSJ_a1c, paige_pharma, emma_london and 30 others
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Dr.KarenChen
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Jul 2, 2025 at 4:05 AM#2

Good question. For Cost-effectiveness analysis GLP-1, here is what the evidence says:

  • The clinical trial data (SURMOUNT program) supports this approach
  • Real-world results from this community generally confirm the trial findings
  • Individual variation is real — give it at least 8 weeks before judging

Happy to go deeper on any of these points if helpful.

14 9JessicaM_2024, TomFromTexas, mike.trainer_LA and 11 others
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NurseKim_ATL
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Jul 2, 2025 at 4:22 AM#3
Dr.KarenChen said:
For Cost-effectiveness analysis GLP-1, here is what the evidence says:The clinical trial data (SURMO

Completely agree with Dr.KarenChen. I would add that Cost-effectiveness analysis also has implications for long-term metabolic health that sometimes get overlooked in these discussions.

In my case, following a similar approach led to significant improvements compared to what I was doing before.

38 23ingrid_STO, pete_nash, hank_denver and 35 others
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WendyG_ATL
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Jul 2, 2025 at 4:39 AM#4

Exactly this. My pharmacist said the same thing about Cost-effectiveness.

26 24AttorneyGrant, DebRD_ATL, KristenIndy and 23 others
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Dr.EM_Chicago
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Jul 2, 2025 at 4:56 AM#5

As a pharmacist, I want to add some clinical context to this discussion on Cost-effectiveness analysis GLP-1.

Building on what SkepticalSean said — the evidence base here is robust. The key publications to reference are from the SUSTAIN program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
48 15lisa_labSD, adam_van, Dr.SurgeonPGH and 45 others
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