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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralSleep quality changes on GLP-1 — November 2025 Page 2

Sleep quality changes on GLP-1 — November 2025

MeganSA_TX Thu, Jan 9, 2025 at 4:42 AM 12 replies 1,551 viewsPage 2 of 3
A1cHero_PHX
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Jan 9, 2025 at 7:32 AM#6

Saving this for reference. Quality thread.

Last edited: Jan 9, 2025 at 12:32 PM
3 24zoe_NC, Dr.ObesityLA, NurseKim_ATL
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labquiet_amy
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Jan 9, 2025 at 7:49 AM#7

Slightly tangential to Sleep quality changes on but nick_SD_fit reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jan 9, 2025 at 9:49 AM
47 14HPLC_Greg, LibrarianMeg, bri_stats and 44 others
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mel_PDX
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Jan 9, 2025 at 8:06 AM#8

+1 to nick_SD_fit. Especially the point about "A few questions about your Sleep quality..." — I have seen the same in my own experience with Sleep quality changes on.

40 13PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 37 others
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Dr.EndoEP
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Jan 9, 2025 at 8:23 AM#9

LibrarianMeg — that is really helpful context on Sleep quality changes on. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jan 9, 2025 at 10:23 AM
26 6Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 23 others
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Dr.SleepRoch
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Jan 9, 2025 at 8:40 AM#10

To answer mel_PDX's question specifically:

From a clinical standpoint, Sleep quality changes on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Jan 9, 2025 at 12:40 PM
3 17roxy_nash, tony_orlando, Dr.NephBHM_UK
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