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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirz made me a completely different person holy cow Page 3

Tirz made me a completely different person holy cow

ZaraB_AL Mon, Jan 19, 2026 at 7:50 PM 26 replies 743 viewsPage 3 of 6
Admin
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Jan 20, 2026 at 12:05 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Jan 20, 2026 at 4:05 AM
46 4PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 43 others
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SleepDoc_PDX
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Jan 20, 2026 at 12:22 AM#12

Clinical perspective on Tirz made me a completely different:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

18 22hank_denver, carlos_SATX, sophie_paris and 15 others
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anders_CPH
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Jan 20, 2026 at 12:39 AM#13
Admin said:
Consult your healthcare provider

I respect Admin perspective but I think this oversimplifies things a bit. Re: Tirz made me a completely — the subgroup analyses show meaningful heterogeneity.

I am not saying Admin wrong entirely — just that the picture is more nuanced than a blanket statement. The STEP data specifically shows dose-dependent variation.

21 12AussieAnna, BethLabQueen, ChrisMacros and 18 others
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mona_PHX
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Jan 20, 2026 at 12:56 AM#14

Reading this thread on Tirz made me a completely hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Tirz made me a — take the leap. It was the best health decision I have ever made. ❤️

49 13CryptoCarl, MariaRD, AussieAnna and 46 others
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tony_orlando
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Jan 20, 2026 at 1:13 AM#15

Bookmarked 📌 The Tirz made me a info in this thread is essential. Coming back to this for sure.

2 22KetoKyle, CanadaChris
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