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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)5mg doing nothing - should I ask to go up? Page 2

5mg doing nothing - should I ask to go up?

nick_newbie Fri, Jan 16, 2026 at 3:31 AM 10 replies 770 viewsPage 2 of 2
julia.endo
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Jan 16, 2026 at 6:21 AM#6
PurityPaulOR said:
— in my experience this comes down to a few key factors

Gonna push back on this one. 5mg doing nothing - should I ask to is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

33 21anna.melb_AU, mark_tokyo, hans_munich and 30 others
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FDA_TrackerJim
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Jan 16, 2026 at 6:38 AM#7

Adding my data to this 5mg doing nothing - discussion:

MetricBaselineMonth 5Month 6
Weight276 lbs246 lbs221 lbs
A1C7.0%6.0%5.2%
hsCRP5.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

20 20Admin, Dr.Martinez, mike_mod and 17 others
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JenPlateau
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Jan 16, 2026 at 6:55 AM#8

NurseAsh_DET — wow. This community is amazing.

28 2RunnerRach, TrialNerd_Beth, HPLC_Greg and 25 others
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TirzTom
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Feb 2024
Florida
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Jan 16, 2026 at 7:12 AM#9

Slightly tangential to 5mg doing nothing - but KarenAZ_mom reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

19 0SandraNC_45, Dr.EndoIndy, tom_AK and 16 others
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mike_mod
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Jan 16, 2026 at 7:29 AM#10

Moderator note: Please keep vendor-specific discussions in the Vendor Reviews section.

I have cleaned up a few off-topic posts. 👍

24 19PurityPaulOR, MaxMetOK, MounjBrad and 21 others
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