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ForumsCardiovascular OutcomesSemaglutide cardiovascular benefit independent of weight loss — looking for input Page 5

Semaglutide cardiovascular benefit independent of weight loss — looking for input

Dr.PeteFamMed Fri, Jan 30, 2026 at 1:38 AM 21 replies 664 viewsPage 5 of 5
pete_nash
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Nashville, TN
Jan 30, 2026 at 8:43 AM#21

hank_denver — that is really helpful context on Semaglutide. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

42 10Admin, Dr.Martinez, mike_mod and 39 others
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JenPlateau
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Missouri
Jan 30, 2026 at 9:00 AM#22

To answer VanRx_Mike's question specifically:

From a clinical standpoint, Semaglutide cardiovascular is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Jan 30, 2026 at 3:00 PM
29 17TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 26 others
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mel_PDX
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Portland, OR
Jan 30, 2026 at 9:17 AM#23

Thank you pete_nash! This is incredibly helpful. Bookmarking for later. 🙏

28 12PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 25 others
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BiostatsBrad
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Durham, NC
Jan 30, 2026 at 9:34 AM#24

Relevant to Semaglutide cardiovascular — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

28 13james_edin, FranDenver, Dr.BariatricHTX and 25 others
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SleepFixSam
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Nov 2024
Hawaii
Jan 30, 2026 at 9:51 AM#25

Slightly tangential to Semaglutide but pete_nash reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

43 24fiona_VT, denise_HTX, raj_cambridge and 40 others
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