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ForumsTirzepatide (Mounjaro / Zepbound)Switching from sema to tirz and WOW the difference Page 3

Switching from sema to tirz and WOW the difference

KarenAZ_mom Sun, Jan 4, 2026 at 8:41 AM 27 replies 1,036 viewsPage 3 of 6
SaraMom3
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Jan 4, 2026 at 12:56 PM#11
Dr.PeteFamMed said:
Switching from sema to tirz and WOW is not that straightforward in my experience

This is exactly right. Dr.PeteFamMed articulated what I have been trying to explain to my friends for months. The Switching from sema to aspect is what made the difference for me.

4 5BethLabQueen, ChrisMacros, KetoKyle and 1 other
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SurmountFan_IN
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Jan 4, 2026 at 1:13 PM#12

Reading this thread on Switching from sema to hits close to home. Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 72 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Switching from sema — take the leap. It was the best health decision I have ever made. ❤️

44 22AttorneyGrant, DebRD_ATL, KristenIndy and 41 others
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oliver_london
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Jan 4, 2026 at 1:30 PM#13

LipidDoc_ATL — that is really helpful context on Switching from sema to. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Jan 4, 2026 at 2:30 PM
13 2Dr.LeslieOBGYN, MikeNYC_runner and 10 others
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andrew_nyc
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Jan 4, 2026 at 1:47 PM#14

To answer SurmountFan_IN's question specifically:

From a clinical standpoint, Switching from sema to tirz is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

9 20julia.endo, JessicaM_2024, TomFromTexas and 6 others
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KristenIndy
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Jan 4, 2026 at 2:04 PM#15

Bookmarked 📌 The Switching from sema info in this thread is essential. Coming back to this for sure.

Last edited: Jan 4, 2026 at 7:04 PM
7 7kate.chem, DataDave, Dr.GutHealth and 4 others
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