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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Switching from sema to tirz and WOW the difference Page 4

Switching from sema to tirz and WOW the difference

KarenAZ_mom Sun, Jan 4, 2026 at 8:41 AM 27 replies 1,036 viewsPage 4 of 6
KarenAZ_mom
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Scottsdale, AZ
Jan 4, 2026 at 2:21 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Switching from sema to.

To answer SurmountFan_IN: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

13 3anna.melb_AU, mark_tokyo, hans_munich and 10 others
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HPLC_Greg
Senior Member
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8,901
Feb 2024
Research Triangle, NC
Jan 4, 2026 at 2:38 PM#17

Adding my data to this Switching from sema to discussion:

MetricBaselineMonth 3Month 6
Weight272 lbs237 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

3 17JenPlateau, SallyK_inj, CryptoCarl
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RetaRick_CA
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Jan 2024
California
Jan 4, 2026 at 2:55 PM#18

Exactly this. My pharmacist said the same thing about Switching from sema.

9 22DadBodDave, AmyNC_wife, SkepticalSean and 6 others
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Dr.ReproEndo
Senior Member
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Jan 2024
Scottsdale, AZ
Jan 4, 2026 at 3:12 PM#19

Slightly tangential to Switching from sema to but SaraMom3 reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

18 19GraceAZ_72, carl_compliance, DanielChem_CHI and 15 others
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jason_sac26
New Member
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Jan 2026
Sacramento, CA
Jan 4, 2026 at 3:29 PM#20

+1 to KarenAZ_mom. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Switching from sema to.

30 21Dr.PulmRoch, maya_sedona, stefan_berlin and 27 others
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