Jan 4, 2026 at 5:11 PM#26
+1. This mirrors my journey exactly. The Switching from sema discussion here is so valuable.
42 4zoe_NC, Dr.ObesityLA, NurseKim_ATL and 39 others
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Jan 4, 2026 at 5:28 PM#27
rick_sfbay said:Night shift nurse — I started at 287 lbs and felt like I would tried everything
I respect rick_sfbay perspective but I think this oversimplifies things a bit. Re: Switching from sema to tirz — the effect size varies considerably by population.
I am not saying rick_sfbay wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.
Last edited: Jan 4, 2026 at 8:28 PM
24 13tane_welly, Dr.PathRoch, mona_PHX and 21 others
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Jan 4, 2026 at 5:45 PM#28
Reading this thread on Switching from sema to hits close to home. Dad of 2 checking in — I started at 273 lbs and felt like I would tried everything.
9 months on tirz and I am a different person. Not just the 48 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Switching from sema — take the leap. It was the best health decision I have ever made. ❤️
Last edited: Jan 4, 2026 at 10:45 PM
37 23rachel_ABQ, traveltech_sara, AttorneyGrant and 34 others
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Sigma-Aldrich — Research-Grade Standards
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Shop Reference StandardsJan 4, 2026 at 6:02 PM#29
Bookmarked 📌 The Switching from sema info in this thread is essential. Coming back to this for sure.
29 12HPLC_Greg, LibrarianMeg, bri_stats and 26 others
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Jan 4, 2026 at 6:19 PM#30
A1cHero_PHX — that is really helpful context on Switching from sema to. Follow-up question: did you experience any side effects during this phase?
I am in a similar situation (about to start) and trying to set realistic expectations.
Last edited: Jan 4, 2026 at 7:19 PM
49 13carlos_SATX, sophie_paris, mel_PDX and 46 others
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