🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Anyone else get super cold on tirz? I am FREEZING Page 3

Anyone else get super cold on tirz? I am FREEZING

tammy_FL Wed, Dec 31, 2025 at 4:26 AM 11 replies 731 viewsPage 3 of 3
NicoleRaleigh
Member
356
1,567
Aug 2024
Raleigh, NC
Dec 31, 2025 at 8:41 AM#11

hannah_MT — wow. This community is amazing.

9 22InsuranceTom, WendyG_ATL, SaraMom3 and 6 others
Reply Quote Save Share Report
mike_nyc
VIP Member
5,678
21,345
Nov 2023
New York
Online
Dec 31, 2025 at 8:58 AM#12

Slightly tangential to Anyone else get super but tammy_FL reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

48 18stefan_berlin, Dr.EM_Chicago, pete_RVA and 45 others
Reply Quote Save Share Report
FranDenver
Member
267
1,123
Oct 2024
Denver, CO
Dec 31, 2025 at 9:15 AM#13

Thanks for sharing this, tammy_FL. A few questions about your Anyone else get experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Anyone else get?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Dec 31, 2025 at 3:15 PM
13 2BariatricNurseD, MASHdoc_SA, GenomicsKate and 10 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
tammy_FL
Member
234
890
Nov 2024
Tampa, FL
Dec 31, 2025 at 9:32 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Anyone else get super.

To answer mike_nyc: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

48 9Dr.PainCLE, mike_mealprep, NicoleRaleigh and 45 others
Reply Quote Save Share Report
hank_denver
Member
278
1,234
Sep 2024
Denver, CO
Dec 31, 2025 at 9:49 AM#15

Relevant to Anyone else get super cold on — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Dec 31, 2025 at 1:49 PM
47 22Dr.DermMIA, fiona_VT, denise_HTX and 44 others
Reply Quote Save Share Report

Similar Threads

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — full results11 replies
SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation6 replies
Tirzepatide dual agonism: GIP + GLP-1 synergistic mechanism18 replies
5mg → 10mg → 15mg titration — clinical guidance and real-world data8 replies
Zepbound insurance coverage — payer-by-payer breakdown 20268 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register