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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊTirzepatide (Mounjaro / Zepbound)β€ΊMy appetite is literally gone is this normal at 10mg

My appetite is literally gone is this normal at 10mg

robert_kc Fri, Dec 26, 2025 at 9:12 PM 12 replies 727 viewsPage 1 of 3
robert_kc
Member
289
1,234
Oct 2024
Kansas City, MO
Dec 26, 2025 at 10:37 PM#1

Anyone else dealing with my appetite is literally gone is from a cost perspective?

I have been paying $280/month and I am trying to get insurance to cover it.

Share what you are paying and what you are getting β€” transparency helps everyone.

1 12PurityPaulOR
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DanielChem_CHI
Senior Member
1,234
5,678
Mar 2024
Chicago, IL
Dec 26, 2025 at 10:54 PM#2

robert_kc's experience with My appetite is literally resonates deeply with mine. I went through almost the identical process β€” starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 68 lbs in 13 months.

One thing I would add that robert_kc did not mention: the relationship with food fundamentally changed.

1 21Dr.DermMIA
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JenPlateau
Member
234
890
Nov 2024
Missouri
Dec 26, 2025 at 11:11 PM#3

Thanks for sharing this, robert_kc. A few questions about your My appetite is experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about My appetite is?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

39 10RunnerRach, TrialNerd_Beth, HPLC_Greg and 36 others
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robert_kc
Member
289
1,234
Oct 2024
Kansas City, MO
Dec 26, 2025 at 11:28 PM#4

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on My appetite is literally.

To answer JenPlateau: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

Last edited: Dec 27, 2025 at 1:28 AM
15 15TomTeleRx, DoseLogDan, SleepFixSam and 12 others
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dave_SLC
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1,567
Aug 2024
Salt Lake City, UT
Dec 26, 2025 at 11:45 PM#5

Relevant to My appetite is literally gone β€” here is my latest bloodwork comparison:

Key improvements: A1C 7.6% β†’ 5.5%, triglycerides 221 β†’ 91 mg/dL, hsCRP 8.0 β†’ 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

35 21Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 32 others
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