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ForumsPublic SquareConstipation on GLP-1: pathophysiology and evidence-based management — November 2025 Page 2

Constipation on GLP-1: pathophysiology and evidence-based management — November 2025

kevin_tulsa Fri, Mar 28, 2025 at 9:07 PM 12 replies 1,370 viewsPage 2 of 3
NicoleRaleigh
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Mar 28, 2025 at 11:57 PM#6

Saving this for reference. Quality thread.

48 2InsuranceTom, WendyG_ATL, SaraMom3 and 45 others
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Dr.SleepRoch
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Mar 29, 2025 at 12:14 AM#7

Slightly tangential to Constipation on GLP-1 but carlos_SATX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

31 24kim_atl_prep, sarah_TO, wendy_avl and 28 others
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RickReta_CO
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Colorado
Mar 29, 2025 at 12:31 AM#8

+1 to carlos_SATX. Especially the point about "A few questions about your Constipation ..." — I have seen the same in my own experience with Constipation on GLP-1.

2 6hyun_seoul, jim_asheville
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nick_SD_fit
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Sep 2024
San Diego, CA
Mar 29, 2025 at 12:48 AM#9

LipidDoc_ATL — that is really helpful context on Constipation on GLP-1. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

6 10PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 3 others
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Dr.SurgeonPGH
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Pittsburgh, PA
Mar 29, 2025 at 1:05 AM#10

To answer RickReta_CO's question specifically:

From a clinical standpoint, Constipation on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Mar 29, 2025 at 4:05 AM
35 4B12Beth, RickReta_CO, PharmHunterJen and 32 others
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