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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 5

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Wed, Dec 17, 2025 at 9:46 PM 36 replies 1,552 viewsPage 5 of 8
Dr.PulmRoch
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Jun 2024
Rochester, MN
Dec 18, 2025 at 4:51 AM#21

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 265 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 55 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

7 4rachel_ABQ, traveltech_sara, AttorneyGrant and 4 others
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maria_elpaso
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Sep 2024
El Paso, TX
Dec 18, 2025 at 5:08 AM#22

BiostatsBrad — that is really helpful context on SURMOUNT-5 Tirzepatide vs. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

16 16RunnerRach, TrialNerd_Beth, HPLC_Greg and 13 others
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SarahChen_PharmD
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Dec 2023
San Diego, CA
Dec 18, 2025 at 5:25 AM#23

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 282 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 62 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

7 6paul_denver, TinaHashiRN, robert_kc and 4 others
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NurseLeah_Nash
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278
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Sep 2024
Nashville, TN
Dec 18, 2025 at 5:42 AM#24

maria_elpaso — that is really helpful context on SURMOUNT-5 Tirzepatide vs. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Last edited: Dec 18, 2025 at 6:42 AM
21 16Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 18 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Dec 18, 2025 at 5:59 AM#25

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 254 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 69 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

8 19mel_PDX, Dr.AddMedPHL, newstart_MO and 5 others
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