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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHeart rate increase on GLP-1 — looking for input Page 5

Heart rate increase on GLP-1 — looking for input

LeilaHI Wed, Dec 31, 2025 at 3:14 AM 28 replies 1,322 viewsPage 5 of 6
RunnerRach
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Aug 2024
Boston, MA
Dec 31, 2025 at 10:19 AM#21

VendorMark — that is really helpful context on Heart rate increase on. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Dec 31, 2025 at 1:19 PM
25 20BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 22 others
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BariatricNurseD
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Feb 2024
Dallas, TX
Online
Dec 31, 2025 at 10:36 AM#22

To answer traveltech_sara's question specifically:

From a clinical standpoint, Heart rate increase on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

10 6roxy_nash, tony_orlando, Dr.NephBHM_UK and 7 others
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InsuranceTom
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Mar 2024
Connecticut
Dec 31, 2025 at 10:53 AM#23

Thank you RunnerRach! This is incredibly helpful. Bookmarking for later. 🙏

28 11Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 25 others
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HPLC_Greg
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Feb 2024
Research Triangle, NC
Dec 31, 2025 at 11:10 AM#24

Relevant to Heart rate increase on GLP-1 — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

43 6Dr.MetabolicMD, RetaRick_CA, JenPlateau and 40 others
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mark_tokyo
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Jun 2024
Tokyo, JP
Dec 31, 2025 at 11:27 AM#25

Slightly tangential to Heart rate increase on but RunnerRach reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

26 11TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 23 others
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