Update on my situation with glp-1 discontinuation weight regain trajectory and — wanted to follow up since some of you asked.

3 weeks since my last post and things have improved significantly. Here is what happened:

Talked to my endo about the concerns raised in my previous thread and they agreed with the community advice.

Full details below. Thanks to everyone who responded last time — your input genuinely made a difference.

KristenIndy's experience with GLP-1 discontinuation resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 50 lbs in 5 months.

One thing I would add that KristenIndy did not mention: the mental health improvements were just as significant.

Thanks for sharing this, KristenIndy. A few questions about your GLP-1 discontinuatio experience:

1. What dose are you currently on?
2. How long before you noticed significant changes?
3. Did your doctor have any specific recommendations about GLP-1 discontin?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 discontinuation.

To answer MeganSA_TX: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to GLP-1 discontinuation weight — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 243 → 113 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.