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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareGLP-1 discontinuation: weight regain trajectory and mitigation strategies — anyone have experience? Page 2

GLP-1 discontinuation: weight regain trajectory and mitigation strategies — anyone have experience?

KristenIndy Fri, Feb 28, 2025 at 7:09 AM 7 replies 1,447 viewsPage 2 of 2
chris_chi24
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Feb 28, 2025 at 9:59 AM#6

Congrats KristenIndy!! Keep going — you're doing incredible. 🎉 👏

44 24nick_newbie, DadBodDave, AmyNC_wife and 41 others
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Dr.GutHealth
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Minnesota
Feb 28, 2025 at 10:16 AM#7

Clinical perspective on GLP-1 discontinuation weight regain:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

27 15tyler_CSCS, VanRx_Mike, steve_okc and 24 others
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mel_PDX
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Dec 2024
Portland, OR
Feb 28, 2025 at 10:33 AM#8

Subscribing to this thread. GLP-1 discontinuation is exactly what I've been researching. 🙏

Last edited: Feb 28, 2025 at 4:33 PM
41 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 38 others
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DerekSJ_a1c
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Aug 2024
San Jose, CA
Feb 28, 2025 at 10:50 AM#9

Reading this thread on GLP-1 discontinuation hits close to home. Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 72 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about GLP-1 discontinuatio — take the leap. It was the best health decision I have ever made. ❤️

37 13traveltech_sara, AttorneyGrant, DebRD_ATL and 34 others
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sean_dublin
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Nov 2024
Dublin, IE
Feb 28, 2025 at 11:07 AM#10
chris_chi24 said:
Keep going — you're doing incredible

This is exactly right. chris_chi24 articulated what I have been trying to explain to my doctor for months. The GLP-1 discontinuation aspect is the most important factor.

17 7quinn_sf, NurseLeah_Nash, gary_naperville and 14 others
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