Dr.PathRoch — that is really helpful context on ClinicalTrials.gov GLP-1. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to ClinicalTrials.gov GLP-1 trial since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 245 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 80 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The ClinicalTrials.gov aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

hank_denver — that is really helpful context on ClinicalTrials.gov GLP-1. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to ClinicalTrials.gov GLP-1 trial since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 262 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 87 lbs, my labs have normalized, and I am off 2 of my 3 medications. The ClinicalTrials.gov aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Just wanted to say — for anyone reading this ClinicalTrials.gov thread who is feeling discouraged: it gets better. The first month are the hardest. Hang in there. 💪