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ForumsCardiovascular OutcomesNNT for MACE prevention — need advice Page 3

NNT for MACE prevention — need advice

MounjBrad Tue, Nov 18, 2025 at 10:36 PM 13 replies 976 viewsPage 3 of 3
RegAffairsDC
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May 2024
Washington, DC
Nov 19, 2025 at 2:51 AM#11

+1 to InsuranceTom. Especially the point about "Re: NNT for MACE prevention need — the ..." — I have seen the same in my own experience with NNT for MACE prevention .

50 7amy_econ_NJ, bbq_ray_KC, oliver_london and 47 others
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dan_philly
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Jul 2024
Philadelphia, PA
Nov 19, 2025 at 3:08 AM#12

Want to share my personal experience related to NNT for MACE prevention need since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 289 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 54 lbs, my labs have normalized, and I am off 2 of my 3 medications. The NNT for MACE aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Nov 19, 2025 at 6:08 AM
27 17AmyNC_wife, SkepticalSean, Dr.CardioMD and 24 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Nov 19, 2025 at 3:25 AM#13

LindaRN_retired — that is really helpful context on NNT for MACE prevention . Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Last edited: Nov 19, 2025 at 5:25 AM
2 11Dr.BariatricHTX, LindaRN_retired
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newstart_MO
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Feb 2026
Springfield, MO
Nov 19, 2025 at 3:42 AM#14

To answer dan_philly's question specifically:

From a clinical standpoint, NNT for MACE prevention need is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

19 11TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 16 others
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patPC_UT
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Park City, UT
Nov 19, 2025 at 3:59 AM#15

Saving this for reference. Quality thread.

Last edited: Nov 19, 2025 at 8:59 AM
43 17julia.endo, JessicaM_2024, TomFromTexas and 40 others
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